Symbyax Oral

• personal or family history of suicide attempts
• breast cancer
• diabetes or family history of diabetes
• heart disease (e.g., chest pain, heart attack, heart failure, irregular heartbeat)
• intestinal problems (e.g., paralytic ileus, chronic constipation)
• kidney disease
• liver problems
• low blood pressure
• neuroleptic malignant syndrome
• narrow-angle glaucoma
• prostate problems
• seizures
• stomach/intestinal ulcers
• brain problems (e.g., dementia, stroke)
• severe loss of body water (dehydration)
• low white blood cell count

This drug may make you dizzy or drowsy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Avoid alcoholic beverages.

To reduce dizziness and lightheadedness, get up slowly when rising from a sitting or lying position, especially when you first start taking this medication.

This medication can make it harder to control your body temperature. Avoid activities that might cause you to overheat (e.g., doing strenuous work, exercising in hot weather, or using hot tubs). Drink plenty of fluids to avoid becoming dehydrated.

Teenagers may be more sensitive to the side effects of this drug, especially weight gain, and also increased amounts of cholesterol, triglycerides and prolactin. See also Side Effects section for more details.

Older adults may be more sensitive to the side effects of this drug, especially a type of mineral imbalance (hyponatremia) that is more common when taking "water pills" or diuretics with this medication.

Use this medication only when clearly needed during pregnancy. It may harm an unborn baby. Also, babies born to mothers who have used this drug during the last 3 months of pregnancy may infrequently develop withdrawal symptoms such as feeding/breathing difficulties, seizures, muscle stiffness, or constant crying. If you notice any of these symptoms in your newborn, tell the doctor promptly.

Since untreated depression can be a serious condition, do not stop taking this medication unless directed by your doctor. If you are planning pregnancy, become pregnant, or think you may be pregnant, immediately discuss the benefits and risks of using this medication during pregnancy with your doctor.

This medication passes into breast milk and may have undesirable effects on a nursing infant. Breast-feeding while using this drug is not recommended. Consult your doctor before breast-feeding.

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