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Orapred ODT Oral

Generic Name: PREDNISOLONE DISINTEGRATING TABLET - ORAL
Pronounced: (pred-NISS-oh-lone)

Orapred ODT Oral Interactions

Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with them first.

This drug should not be used with the following medications because very serious interactions may occur:

  • live virus vaccines
  • natalizumab


If you are currently using the medications listed above, tell your doctor or pharmacist before starting prednisolone.

Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially:

  • aldesleukin
  • large doses of aspirin and aspirin-like drugs (salicylates)
  • birth control pills
  • "blood thinners" (e.g., warfarin)
  • bupropion
  • diabetes medications
  • estrogen hormone replacement
  • herbal products (e.g., licorice)
  • isoniazid
  • mifepristone
  • nonsteroidal anti-inflammatory drugs (NSAIDs such as indomethacin, ibuprofen)
  • drugs affecting liver enzymes that remove prednisolone from your body (such as ephedrine, erythromycin, azole antifungals including ketoconazole, barbiturates including phenobarbital, rifamycins including rifampin, certain anti-seizure medications including phenytoin)
  • drugs that may cause potassium loss (e.g., amphotericin B, "water pills" such as hydrochlorothiazide or furosemide)
  • quinolone antibiotics (e.g., ciprofloxacin, levofloxacin)


Check all prescription and nonprescription medicine labels carefully since many medications contain pain relievers/fever reducers (NSAIDs such as aspirin, ibuprofen, or naproxen) that may increase the risk of stomach bleeding. Low-dose aspirin should be continued if prescribed by your doctor for specific medical reasons such as heart attack or stroke prevention (usually at dosages of 81-325 milligrams per day). Consult your doctor or pharmacist for more details.

This medication may interfere with certain laboratory tests, possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this drug.

This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.

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