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Trexall Oral

Trexall Oral Precautions

Before taking methotrexate, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have:

  • liver disease
  • severe kidney disease
  • severe lung disease (e.g., pulmonary fibrosis)
  • alcohol use
  • suppressed immune system
  • blood cell/bone marrow disorders


Before using this medication, tell your doctor or pharmacist your medical history, especially of:

  • stomach/intestinal diseases (e.g., peptic ulcer, ulcerative colitis)
  • kidney disease
  • any active infection (including chickenpox or recent exposure to it)
  • folic acid deficiency


This drug may make you dizzy or drowsy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Avoid alcoholic beverages.

This medication may make you more sensitive to the sun. Avoid prolonged sun exposure, tanning booths or sunlamps. Use a sunscreen and wear protective clothing when outdoors.

Do not have immunizations/vaccinations without the consent of your doctor and avoid contact with people who have recently received oral polio vaccine.

Use caution with sharp objects like safety razors or nail cutters and avoid activities such as contact sports to lower the chance of getting cut, bruised, or injured.

Wash your hands well to prevent the spread of infections.

Methotrexate must not be used during pregnancy. It may cause harm to an unborn baby. If you become pregnant or think you may be pregnant, inform your doctor immediately. Pregnancy must be avoided, therefore males and females must use reliable form(s) of birth control during and for at least 3 months following the end of methotrexate treatment.

Methotrexate passes into breast milk. Due to the risk to the infant, do not breast-feed while using this medication.

Trexall Oral Medical Alert

Your condition can cause complications in a medical emergency. For enrollment information call MedicAlert at 1-800-854-1166 (USA), or 1-800-668-1507 (Canada).

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