Methotrexate Oral

In Depth

When used to treat tumors, methotrexate sometimes causes side effects due to the rapid destruction of cancer cells (tumor lysis syndrome). Tell your doctor immediately if you experience symptoms such as irregular heartbeat or muscle weakness.

Although rare, this medication when used with radiation treatment may increase the risk of tissue and bone damage. Discuss the risks and benefits of your treatment plan with your doctor.

Methotrexate Oral Side Effects

See also Warning section.

Nausea, vomiting, stomach pain, drowsiness or dizziness may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor immediately if any of these serious side effects occur:

mouth sores
diarrhea
fever
fatigue
persistent sore throat
unusual bleeding or bruising
black stools
skin rash
enlarged glands/lymph nodes
dark urine
bone pain
unusual pain and discoloration of the skin

Tell your doctor immediately if any of these unlikely but serious side effects occur:

yellowing eyes/skin
change in the amount of urine
chest pain
dry cough
trouble breathing
calf pain/swelling
vision changes
irregular heartbeat
muscle weakness
mental/mood changes
seizures

Temporary hair loss may occur. Normal hair growth should return after treatment has ended.

A serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction include: