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Zyrtec-D Oral

Generic Name: PSEUDOEPHEDRINE/CETIRIZINE EXTENDED-RELEASE - ORAL
Pronounced: (sue-doh-eff-ED-rin/seh-TEER-ah-zeen)

Zyrtec-D Oral Interactions

Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with them first.

This drug should not be used with or within 14 days of taking MAO inhibitors (e.g., furazolidone, linezolid, moclobemide, phenelzine procarbazine, rasagiline, selegiline, isocarboxazid, tranylcypromine).

Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription products you may use, especially of:

  • adrenalin-like drugs (e.g., ephedrine, methylphenidate)
  • antihistamines applied to the skin (such as diphenhydramine cream, ointment, spray)
  • certain blood pressure drugs (e.g., methyldopa, guanethidine, reserpine, beta-blockers such as propranolol)
  • certain herbal products (e.g., ephedra)


Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription products you may use, especially of drugs that cause drowsiness such as:

  • anti-anxiety drugs (e.g., diazepam)
  • other antihistamines that cause drowsiness (e.g., diphenhydramine)
  • anti-seizure drugs (e.g., carbamazepine)
  • medicine for sleep (e.g., sedatives)
  • muscle relaxants
  • narcotic pain relievers (e.g., codeine)
  • psychiatric medicines (e.g., phenothiazines such as chlorpromazine, or tricyclics such as amitriptyline)
  • tranquilizers


Check the labels on all your medicines (e.g., cough-and-cold products, diet aids) because they may contain ingredients that could cause drowsiness or increase your heart rate or blood pressure. Ask your pharmacist about the safe use of those products.

This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.

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