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Flolan IV

In Depth

Generic Name: EPOPROSTENOL - INJECTION
Pronounced: (ep-oh-PRAW-steh-nol)

Flolan IV Side Effects

Nausea, headache, vomiting, loss of appetite, diarrhea, dizziness, jaw pain, flushing, sweating, drowsiness, joint/muscle aches, or redness/swelling/pain at the injection site may occur. If any of these effects persist or worsen, notify your doctor promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor immediately if any of these serious side effects occur:

  • stomach pain
  • chest pain
  • vision changes
  • fast/slow/irregular pulse
  • mental/mood changes
  • changes in the appearance of the skin (e.g., unusual paleness or blue/grey color)
  • signs of flu (e.g., chills, fever, sore throat)
  • unusual bleeding or bruising
  • tingling /numbness/loss of feeling in hands or feet


Tell your doctor immediately if any of these unlikely but serious side effects occur:

  • unusual fatigue or weakness
  • enlarged abdomen
  • unexplained weight gain/loss


An allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of an allergic reaction include: rash, itching, swelling, severe dizziness, trouble breathing.

Do not suddenly stop using this medication or decrease the dose unless directed to do so by your doctor. Serious effects such as trouble breathing, dizziness, or weakness may occur, which rarely may lead to death, if this medication is suddenly stopped or interrupted even briefly. Contact your doctor or pharmacist immediately if your dose is interrupted or if you develop these side effects.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

Flolan IV Medical Alert

Your condition can cause complications in a medical emergency. For enrollment information call MedicAlert at 1-800-854-1166 (USA), or 1-800-668-1507 (Canada).

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