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Zestoretic Oral

Generic Name: LISINOPRIL/HYDROCHLOROTHIAZIDE - ORAL
Pronounced: (lyse-IN-oh-pril/HI-dro-klor-oh-THIGH-uh-zide)

Zestoretic Oral Warning

This drug can cause serious (possibly fatal) harm to an unborn baby if used during pregnancy. Therefore, it is important to prevent pregnancy while taking this medication. Consult your doctor for more details and to discuss the use of reliable forms of birth control while taking this medication. If you are planning pregnancy, become pregnant, or think you may be pregnant, contact your doctor immediately.

Zestoretic Oral Side Effects

Dizziness, lightheadedness, tiredness, or headache may occur as your body adjusts to the medication. Dry cough may also occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor immediately if any of these unlikely but serious side effects occur:

  • extreme thirst
  • very dry mouth
  • muscle cramps/weakness
  • swelling of the hands/feet
  • fast/slow/irregular heartbeat
  • fainting
  • muscle/joint aches
  • tingling/numbness of the hands/feet


Tell your doctor immediately if any of these rare but very serious side effects occur:

  • signs of infection (e.g., fever, chills, persistent sore throat)
  • yellowing eyes/skin
  • dark urine
  • severe stomach/abdominal pain
  • persistent tiredness
  • persistent nausea/vomiting
  • easy bruising/bleeding
  • unusual change in the amount of urine (not including the normal increase in urine when you first start this drug)
  • seizures


A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including:

  • rash
  • itching
  • swelling (especially of the face, lips, tongue, or throat)
  • severe dizziness
  • trouble breathing


This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

Zestoretic Oral Medical Alert

Your condition can cause complications in a medical emergency. For information about enrolling in MedicAlert, call 1-800-854-1166 (USA) or 1-800-668-1507 (Canada).

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