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Ziconotide IT

In Depth

Generic Name: ZICONOTIDE - INJECTION
Pronounced: (zico-NO-tide)

Ziconotide IT Warning

Severe mental/mood changes (e.g., confusion, depression, hallucinations, decreased alertness) may occur in some patients. This medication should not be used if you have a history of certain mental disorders (e.g., psychosis) because it increases the risk of those side effects. (See also Side Effects, Precautions sections.)

Ziconotide IT Side Effects

Dizziness, drowsiness, nausea, headache, and weakness may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor immediately if any of these unlikely but serious side effects occur:

  • decreased alertness (unresponsiveness)
  • confusion
  • memory problems
  • mental/mood changes (e.g., anxiety, depression, hallucinations, thoughts of suicide)
  • new or worsening muscle pain/soreness
  • numbness/tingling
  • trouble speaking/swallowing
  • difficult/unsteady walking
  • trouble urinating
  • dark urine
  • vision changes


A very serious infection (meningitis) may occur if the site of your infusion or the solution going into your spinal cord becomes contaminated. Symptoms of meningitis include mental changes (e.g., extreme drowsiness, confusion), high fever, seizures, severe headache, stiff neck, nausea, and vomiting. Seek immediate medical attention if any of these unlikely but very serious side effects occur.

A very serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction may include:

  • rash
  • itching
  • swelling
  • severe dizziness
  • trouble breathing


This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

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