Ibuprofen-Oxycodone Oral

In Depth

This drug may rarely cause serious (possibly fatal) liver disease. If you notice any of the following highly unlikely but very serious side effects, stop taking this medication and consult your doctor or pharmacist immediately:

yellowing eyes/skin
dark urine
unusual/extreme tiredness
persistent nausea/vomiting

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including:

rash
itching/swelling (especially of the face/tongue/throat)
severe dizziness
trouble breathing

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Ibuprofen-Oxycodone Oral Precautions

Before taking this medication, tell your doctor or pharmacist if you are allergic to oxycodone or ibuprofen; or to other narcotic pain relievers (such as codeine, hydrocodone); or to aspirin or other NSAIDs (such as naproxen, celecoxib); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of:

intestinal/bowel disorders (such as paralytic ileus, infectious diarrhea, colitis, blockage)
recent heart bypass surgery (CABG)
kidney disease
liver disease
bleeding/blood-clotting disorders (such as hemophilia, vitamin K deficiency, low platelet count)
stomach/intestine/esophagus problems (such as bleeding, ulcers, recurring heartburn)
diabetes
gout
lung diseases (such as asthma, chronic obstructive pulmonary disease-COPD)
breathing problems (such as slow/shallow breathing, sleep apnea)
growths in the nose (nasal polyps)
a certain spinal problem (kyphoscoliosis)
certain heart problems (such as low blood pressure, irregular heartbeat)
personal or family history of regular use/abuse of drugs/alcohol/other substances
brain disorders (such as seizures, head injury, tumor, increased intracranial pressure)
underactive thyroid (hypothyroidism)
difficulty urinating (for example, due to enlarged prostate or narrowed urethra)
disease of the pancreas (such as pancreatitis)
mental/mood disorders (such as toxic psychosis)
gallbladder disease
adrenal gland problem (such as Addison's disease)
certain enzyme deficiencies (pyruvate kinase or G6PD deficiency)