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Crinone Vagl

In Depth

Generic Name: PROGESTERONE 4% GEL - VAGINAL
Pronounced: (pro-JESS-ter-own)

Crinone Vagl Side Effects

Bloating, cramps, stomach pain, constipation, diarrhea, nausea, breast swelling/pain, pain around the vaginal area, drowsiness, tiredness, decreased interest in sex, joint pain, or headache may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.

You may develop a vaginal discharge containing little white balls of gel from using this medication. This is normal and harmless. However, if you develop any unusual vaginal discharge, itching, or odor, notify your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor immediately if any of these unlikely but serious side effects occur:

  • mental/mood changes (e.g., depression, nervousness, mood swings)
  • signs of water weight gain (e.g., swollen feet/ankles)
  • increased urination at night
  • abnormal vaginal bleeding
  • breast lumps
  • yellowing of the eyes or skin


Seek immediate medical attention if any of these rare but very serious side effects occur:

  • pain/redness/swelling of arms or legs
  • trouble breathing
  • chest pain
  • weakness on one side of the body
  • slurred speech
  • vision changes


A very serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction may include:

  • rash
  • itching
  • swelling
  • severe dizziness
  • trouble breathing


This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

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