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Trifluoperazine Oral

In Depth

Generic Name: TRIFLUOPERAZINE - ORAL CONCENTRATE
Pronounced: (trye-flooh-oh-PER-a-zeen)

Trifluoperazine Oral Side Effects

Drowsiness, dizziness, dry mouth, blurred vision, tiredness, nausea, constipation, and trouble sleeping may occur. You may also be more sensitive to sunburn and less able to tolerate heat/strenuous exercise (see Precautions section). If any of these effects persist or worsen, notify your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Careful monitoring by your doctor may decrease your risk.

Tell your doctor immediately if any of these unlikely but serious side effects occur:

  • feelings of restlessness/agitation/jitteriness
  • mask-like facial expression
  • shuffling walk
  • drooling
  • uncontrolled shaking of the hands
  • twitching in the face
  • muscle spasm/weakness
  • trouble swallowing
  • uncontrollable movements of the mouth/face/hands
  • unusual mental/mood changes (e.g., depression, worsening of psychosis)
  • unusual dreams
  • trouble urinating
  • severe constipation
  • severe stomach/abdominal pain
  • weight gain
  • swelling of the feet/ankles
  • nipple discharge
  • swollen/tender breasts
  • changes in menstrual flow
  • decreased sexual ability
  • fast/pounding heartbeat with headache
  • severe dizziness
  • butterfly-shaped facial rash
  • joint/muscle pain
  • confusion
  • darkening of skin color
  • vision changes
  • fainting


For males, in the very unlikely event you have a painful, prolonged erection (lasting more than 4 hours), stop using this drug and seek immediate medical attention or permanent problems could occur.

Tell your doctor immediately if any of these rare but very serious side effects occur:

  • signs of infection (e.g., fever, persistent sore throat)
  • yellowing of the eyes/skin
  • dark urine
  • severe stomach/abdominal pain
  • unusual bleeding/bruising
  • chest pain
  • seizures
  • confusion


This drug may infrequently cause a serious (sometimes fatal) nervous system problem (neuroleptic malignant syndrome). Seek immediate medical attention if you notice any of the following rare but very serious side effects:

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