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Imipramine Pamoate Oral

In Depth



Tell your doctor immediately if any of these rare but very serious side effects occur:

  • easy bruising/bleeding
  • signs of infection (e.g., fever, persistent sore throat)
  • severe stomach/abdominal pain
  • dark urine
  • yellowing of eyes/skin


Seek immediate medical attention if any of these rare but very serious side effects occur:

  • chest pain
  • slow/fast/irregular heartbeat
  • fainting
  • seizures
  • slurred speech
  • weakness on one side of the body
  • vision changes


A very serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction include:

  • rash
  • itching/swelling (especially of the face/tongue/throat)
  • severe dizziness
  • trouble breathing


This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Imipramine Pamoate Oral Precautions

Before taking this medication, tell your doctor or pharmacist if you are allergic to it; or to other tricyclic antidepressants (e.g., amitriptyline); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have a certain medical condition. Before using this medicine, consult your doctor or pharmacist if you have had:

  • a recent heart attack


Before using this medication, tell your doctor or pharmacist your medical history, especially of:

  • breathing problems (e.g., asthma, chronic bronchitis)
  • certain eye problems (e.g., glaucoma, increased intraocular pressure)
  • diabetes
  • eating disorders (e.g., bulimia)
  • heart problems (e.g., arrhythmias, coronary artery disease)
  • liver problems
  • kidney problems
  • personal or family history of other mental/mood conditions (e.g., bipolar disorder, schizophrenia)
  • seizures
  • overactive thyroid (hyperthyroidism)
  • trouble urinating (e.g., due to enlarged prostate)
  • any condition that may increase your risk of seizures (e.g., alcohol/sedative dependency, use of electroconvulsive therapy, brain injury/disease such as stroke)
  • certain types of tumors (e.g., pheochromocytoma, neuroblastoma)
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