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Parnate Oral

  • severe stomach/abdominal pain
  • persistent nausea/vomiting
  • seizures
  • dark urine
  • yellowing eyes/skin


This drug may rarely cause an attack of extremely high blood pressure (hypertensive crisis), which may be fatal. Many drug and food interactions can increase this risk (See also Drug Interaction section.) Stop taking tranylcypromine and seek immediate medical attention if any of these serious side effects occur:

  • frequent/severe headache
  • fast/slow/irregular/pounding heartbeat
  • chest pain
  • neck stiffness/soreness
  • severe nausea/vomiting
  • sweating/clammy skin (sometimes with fever)
  • widened pupils
  • sudden sensitivity to light (photophobia)


A serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction include:

  • rash
  • itching/swelling (especially of the face/tongue/throat)
  • dizziness
  • trouble breathing


This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Parnate Oral Precautions

Before taking tranylcypromine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have:

  • a certain kind of adrenal gland tumor (pheochromocytoma)
  • cerebrovascular disease (e.g., stroke)
  • heart problems (e.g., congestive heart failure, heart attack)
  • high blood pressure
  • history of severe/frequent headaches
  • liver problems


Before using this medication, tell your doctor or pharmacist your medical history, especially of:

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