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Nafcillin IV

In Depth

Generic Name: NAFCILLIN - INJECTION
Pronounced: (naff-SIL-in)

Nafcillin IV Side Effects

If this medication is injected into a muscle, pain at the injection site may occur. If this effect persists or worsens, notify your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor immediately if any of these unlikely but serious side effects occur:

  • pain/swelling/skin peeling at injection site (if this drug is injected into a vein)
  • joint/muscle pain
  • dark/cloudy urine
  • change in the amount of urine


Tell your doctor immediately if any of these rare but very serious side effects occur:

  • extreme tiredness
  • easy bruising/bleeding
  • new signs of infection (e.g., fever, persistent sore throat)
  • seizures
  • uncontrolled movements
  • confusion
  • irregular heartbeat
  • muscle cramps
  • weakness


This medication may rarely cause a severe intestinal condition (pseudomembranous colitis) due to a type of resistant bacteria. This condition may occur during treatment or weeks to months after treatment has stopped. Do not use anti-diarrhea products or narcotic pain medications if you have any of the following symptoms because these products may make them worse. Tell your doctor immediately if you develop:

  • persistent diarrhea
  • abdominal or stomach pain/cramping
  • blood/mucus in your stool


Use of this medication for prolonged or repeated periods may result in oral thrush or a new vaginal yeast infection. Contact your doctor if you notice white patches in your mouth, a change in vaginal discharge, or other new symptoms.

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including:

  • rash
  • itching/swelling (especially of the face/tongue/throat)
  • severe dizziness
  • trouble breathing


This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

Call your doctor for medical advice about side effects. In the US, you may report side effects to the Food and Drug Administration (FDA) at 1-800-FDA-1088.

In Canada, you may report side effects to Health Canada at 1-866-234-2345.

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