Paliperidone Oral
This drug may infrequently cause a serious (rarely fatal) nervous system disorder (neuroleptic malignant syndrome). Seek immediate medical attention if you notice any of the following rare but very serious side effects:
- muscle stiffness/pain
- high fever
- increased sweating
- mental/mood changes
- change in the amount of urine
Rarely, this medication may increase your blood level of a certain hormone (prolactin). In females, an increase in prolactin levels may result in unwanted breast milk, missed/stopped periods, or difficulty becoming pregnant. In males, it may result in decreased sexual ability, inability to produce sperm, or enlarged breasts. If you develop any of these symptoms, tell your doctor immediately.
For males, in the very unlikely event you have a painful or prolonged erection (lasting more than 4 hours), stop using this drug and seek immediate medical attention, or permanent problems could occur.
A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including:
- rash
- itching/swelling (especially of the face/tongue/throat)
- severe dizziness
- trouble breathing
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
In the US -
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
Paliperidone Oral Precautions
Before taking paliperidone, tell your doctor or pharmacist if you are allergic to it; or to risperidone; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of:
- severe liver disease
- kidney disease
- esophagus/stomach/intestinal movement or blockage disorders (e.g., difficulty swallowing, diarrhea, peritonitis, cystic fibrosis, Meckel's diverticulum)
- a severe loss of body water (dehydration)
- blood pressure problems
- disease of the blood vessels in the brain (e.g., stroke)
- heart disease (e.g., ischemic heart disease)
- seizures
- breast cancer
- Parkinson's disease
- Alzheimer's disease
- low white blood cell count
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