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Pylera Oral

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Generic Name: BISMUTH SUBCITRATE/METRONIDAZOLE/TETRACYCLINE - ORAL
Pronounced: (BIZ-muth sub-SIT-rate/meh-troh-NID-uh-zole/teh-truh-SYE-kleen)

Pylera Oral Side Effects

Nausea, diarrhea, upset stomach, abdominal pain, changes in taste, headache, or dizziness may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Your tongue may turn dark in color while you are taking this medication. This is harmless, and the effect will disappear when you stop the medication.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor immediately if any of these unlikely but serious side effects occur:

  • numbness/tingling of arms/legs
  • discolored teeth
  • mental/mood changes (e.g., anxiety, irritability, depression)
  • difficult/painful swallowing
  • heartburn
  • fast/pounding heartbeat
  • ringing in the ears
  • frequent/painful urination


Tell your doctor immediately if any of these rare but very serious side effects occur:

  • severe headache
  • vision changes (e.g., blurred vision)
  • change in the amount of urine
  • signs of infection (e.g., fever, persistent sore throat)
  • easy bruising/bleeding
  • dark urine
  • yellowing eyes/skin
  • persistent nausea/vomiting
  • severe stomach/abdominal pain
  • unusual weakness/tiredness
  • seizures
  • chest pain


This product commonly causes dark stools that are usually not serious. However, you may not be able to tell this effect apart from blood in the stool, which could be a sign of a serious condition. Therefore, tell your doctor immediately if you have dark stools.

This medication may rarely cause a severe intestinal condition (pseudomembranous colitis) due to a type of resistant bacteria. This condition may occur weeks after treatment has stopped. Tell your doctor immediately if you develop persistent diarrhea, abdominal or stomach pain/cramping, or blood/mucus in your stool. Do not use anti-diarrhea products or narcotic pain medications if you have any of these symptoms because these products may make them worse.

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