Depo-Estradiol IM
In Depth
- Uses and How to Use
- Dosage and Storage
- Precautions and Side Effects
- Drug Interactions
- Drug Images
Pronounced: (ES-tra-DYE-ol sip-EYE-oh-nate)
Depo-Estradiol IM Warning
Estrogens given alone and with another hormone (progestin) for replacement treatment after menopause have sometimes caused rare but very serious side effects. Discuss the risks and benefits of hormone treatment and your personal health history with your doctor.
Estrogens have been reported to increase the chance of cancer of the uterus (endometrial cancer). Taking a progestin with estrogen decreases this risk. Tell your doctor immediately if you have any unusual vaginal bleeding.
Estrogens may also increase your risk for cancer of the ovaries, stroke, dementia, and serious blood clots in the legs. Estrogen given in combination with progestin can infrequently cause heart disease (such as heart attacks), stroke, serious blood clots in the lungs/legs/pelvis, dementia, and breast cancer. Some of these risks appear to depend on the length of time this drug is used and the amount of estrogen per dose. To reduce your risk for serious side effects, use this medication for the shortest possible length of time at the lowest effective dose. Talk with your doctor about the details and check with him/her regularly (such as every 3 to 6 months) to see if you still need to use this medication.
Estrogen treatment alone does not appear to increase your risk of breast cancer when used for up to 7 years after menopause. However, talk to your doctor about the risks if you need to use estrogen for a longer period.
Products that contain estrogen should not be used to prevent heart disease or dementia.
If you use this drug for an extended period, you should have regular physical exams and medical tests. See also Notes section.
Depo-Estradiol IM Side Effects
See also Warning section.
Dizziness, lightheadedness, headache, stomach upset, bloating, nausea, vaginal bleeding/spotting, weight changes, increased/decreased interest in sex, or breast tenderness may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.
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