Depo-Estradiol IM

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if you have any serious side effects, including:

• breast lumps
• mental/mood changes (such as depression, memory loss)
• abdominal pain/swelling/tenderness
• swelling of hands/feet
• unusual tiredness
• unusual vaginal discharge/itching/odor

Get medical help right away if any of these rare but serious side effects occur:

• sudden severe headache
• sudden vision changes (such as double vision, blindness or worsening vision, change in contact lens fit)
• symptoms of a heart attack (such as chest/jaw/left arm pain, shortness of breath, unusual sweating)
• symptoms of a stroke (such as weakness on one side of the body, slurred speech, confusion)
• unusual leg pain/redness/swelling/warmth

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including:

• rash
• itching/swelling (especially of the face/tongue/throat)
• severe dizziness
• trouble breathing

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Depo-Estradiol IM Precautions

Before using estradiol cypionate, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of:

• asthma
• blood clots
• cancer (including family history)
• high blood cholesterol/fat (triglyceride) levels
• diabetes
• gallbladder disease
• heart disease (such as congestive heart failure, previous heart attack)
• high blood pressure
• kidney disease
• liver problems
• lupus
• migraines
• mental/mood disorders (such as dementia, depression)
• mineral imbalance (low/high level of calcium in the blood)
• seizures
• stroke
• a certain blood disorder (porphyria)
• a certain hormone problem (hypoparathyroidism)
• underactive thyroid (hypothyroidism)
• uterus problems (such as uterine fibroids, endometriosis)
• vaginal symptoms (such as unusual bleeding)
• yellowing eyes/skin (cholestatic jaundice) during pregnancy or with past estrogen use

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Drug Interactions