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Progesterone Micronized Oral

  • family medical history (especially breast lumps and cancer)
  • kidney disease
  • obesity
  • heart disease (e.g., past heart attacks, coronary artery disease, congestive heart failure)
  • high blood pressure
  • seizures
  • migraine headaches
  • asthma
  • high blood levels of cholesterol/fats
  • depression
  • diabetes
  • strokes
  • lupus


This drug may make you dizzy or drowsy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit alcoholic beverages.

Notify your doctor beforehand if you will be having surgery or will be confined to a chair/bed for a long time (e.g., a long plane flight). You may need to stop the medication for a time or take special precautions because of the increased risk for blood clots. Ask your doctor for more details.

Do not smoke. Smoking combined with this medication further increases your risk for strokes, blood clots, high blood pressure, and heart attacks.

This medication may cause blotchy, dark areas on your skin (melasma). Sunlight may worsen this effect. Avoid prolonged sun exposure, tanning booths, and sunlamps. Use a sunscreen, and wear protective clothing when outdoors.

This medication may be used during pregnancy only as directed by your doctor. There is conflicting information about whether progestins may cause harm to an unborn baby. Discuss the risks and benefits with your doctor.

This drug passes into breast milk. Consult your doctor before breast-feeding.

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