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Arthrotec 50 Oral

Stop taking this medication and seek immediate medical attention if you notice any of the following rare but very serious side effects: black stools, persistent stomach/abdominal pain, vomit that looks like coffee grounds, chest pain, shortness of breath, weakness on one side of the body, sudden vision changes, slurred speech.

This medication should not be used right before or after heart bypass surgery.

Arthrotec 50 Oral Side Effects

See also Warning section.

Diarrhea and upset stomach may occur within a few weeks after you start taking this medication, and usually last for about 1 week. See How to Use for ways to reduce diarrhea.

Nausea, heartburn, gas, stomach pain, constipation, headache, tiredness, drowsiness, and dizziness may also occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Rarely, diarrhea can become so severe and persistent that it may lead to a large loss of your body's water and minerals (dehydration). Be sure to drink plenty of fluids and get enough minerals/electrolytes to prevent dehydration. Tell your doctor immediately if you develop any of the following signs:

  • severe/persistent diarrhea
  • stomach cramps
  • severe dizziness
  • decreased amount of urine
  • muscle weakness


Tell your doctor immediately if any of these unlikely but serious side effects occur:

  • difficult/painful swallowing
  • swelling of the hands/feet
  • sudden/unexplained weight gain
  • vision changes
  • hearing changes (e.g., ringing in the ears)
  • mental/mood changes (e.g., depression)
  • fast/pounding heartbeat
  • persistent/severe headache
  • fainting
  • unusual/heavy vaginal bleeding
  • menstrual problems/irregular periods


Tell your doctor immediately if any of these rare but very serious side effects occur:

  • change in the amount of urine
  • easy bruising/bleeding
  • signs of infection (e.g., fever, persistent sore throat)
  • unexplained stiff neck
  • seizures
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