Arthrotec 50 Oral

In Depth

This drug may rarely cause serious (possibly fatal) liver disease. If you notice any of the following rare but very serious side effects, stop taking diclofenac/misoprostol and tell your doctor immediately:

yellowing eyes/skin
dark urine
unusual/extreme tiredness
severe stomach/abdominal pain
persistent nausea/vomiting

A very serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction may include:

rash
itching/swelling (especially of the face/tongue/throat)
severe dizziness
trouble breathing

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Arthrotec 50 Oral Precautions

Before taking diclofenac/misoprostol, tell your doctor or pharmacist if you are allergic to either of these drugs; or to aspirin or other NSAIDs (e.g., ibuprofen, naproxen, celecoxib); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have:

aspirin-sensitive asthma (a history of worsening breathing with runny/stuffy nose after taking aspirin or other NSAIDs)
recent heart bypass surgery (CABG)
certain liver problem (hepatic porphyria)

Before using this medication, tell your doctor or pharmacist your medical history, especially of:

kidney disease
liver disease
poorly controlled diabetes
stomach/intestine/esophagus problems (e.g., bleeding, ulcers, inflammatory bowel disease)
heart disease (e.g., congestive heart failure, history of heart attack)
high blood pressure
stroke
swelling (edema, fluid retention)
a severe loss of body water (dehydration)
blood disorders (e.g., anemia)
bleeding or clotting problems
asthma
growths in the nose (nasal polyps)