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Bicillin L-A IM

In Depth

Generic Name: PENICILLIN G BENZATHINE - INJECTION
Pronounced: (pen-ih-SILL-in G BEN-zuh-theen)

Bicillin L-A IM Warning

This medication must not be injected into a vein or mixed with solutions that will be injected into a vein.

Bicillin L-A IM Side Effects

Pain at the injection site, nausea, or vomiting may occur. If these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor immediately if any of these unlikely but serious side effects occur:

  • severe pain/peeling skin at injection site
  • joint/muscle pain
  • headache
  • shortness of breath
  • dizziness


Tell your doctor immediately if any of these rare but very serious side effects occur:

  • vision changes
  • fast/slow/pounding heartbeat
  • numbness/tingling of arms/legs
  • pain/redness/swelling of arms or legs
  • change in skin color near injection site or on arms/legs
  • uncontrolled movements
  • inability to move
  • change in the amount of urine
  • new signs of infection (e.g., fever, persistent sore throat)
  • easy bruising/bleeding
  • extreme tiredness
  • dark/cloudy urine
  • seizures
  • mental/mood changes (e.g., depression, agitation)


Seek immediate medical attention if any of these rare but very serious side effects occur:

  • trouble breathing
  • chest pain
  • slurred speech
  • confusion
  • fainting


If used to treat syphilis, this medication may cause a condition known as Jarisch-Herxheimer reaction. This condition may occur 1 to 2 hours after you receive the medication and can last up to 24 hours. Notify your doctor immediately if you experience any of these symptoms: fever/chills, muscle pain, worsening of skin sores, fast heartbeat, fast breathing, dizziness, flushing.

This medication may rarely cause a severe intestinal condition (Clostridium difficile-associated diarrhea) due to a type of resistant bacteria. This condition may occur during treatment or weeks to months after treatment has stopped. Do not use anti-diarrhea products or narcotic pain medications if you have any of the following symptoms because these products may make them worse. Tell your doctor immediately if you develop:

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