Valproate Sodium IV

In Depth

Uses and How to Use
Precautions and Side Effects
Dosage and Storage

Generic Name: VALPROATE SODIUM - INJECTION
Pronounced: (val-PROE-ate SOE-dee-um)

Valproate Sodium IV Warning

Rarely, serious (sometimes fatal) liver problems have occurred in patients using this drug. Children under 2 years of age who are using this drug are at higher risk for these liver problems, especially if they have a severe seizure disorder with mental retardation; are using more than one anti-seizure drug; have body process (metabolic) problems; or have brain disorders. If this drug is used in these patients, do not use additional anti-seizure drugs.

Early signs of liver problems include: loss of seizure control, vomiting, unusual tiredness/weakness, loss of appetite, yellowing eyes or skin, or swelling of the face. Contact your doctor promptly if you develop any of these symptoms.

Liver tests should be done before starting, and during the use of this drug.

Rarely, severe (sometimes fatal) swelling of the pancreas (pancreatitis) has occurred in some people while taking this drug. Tell your doctor immediately if you develop severe stomach pain, vomiting, and loss of appetite.

Rarely, severe (sometimes fatal) encephalopathy (decreased mental status) has occurred during use of this medication. This has occurred in patients with a specific metabolic disorder (urea cycle disorder). Symptoms may include unusual weakness, vomiting, or mental changes. Contact your doctor promptly if you develop any of these symptoms.

This medication can cause birth defects. Discuss the risks and benefits of this medication with your doctor, especially if it prescribed for a condition other than seizure disorder (e.g., migraine headache). (See also Precautions section.)

Valproate Sodium IV Side Effects

Nausea, drowsiness, dizziness, headache, diarrhea, or pain/redness/swelling at the injection site, altered taste, sweating, or nervousness may occur. If any of these effects persist or worsen, notify your doctor promptly.

Remember that your doctor has prescribed this medication because the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

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