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Declomycin Oral

Generic Name: DEMECLOCYCLINE - ORAL
Pronounced: (dem-eh-klo-SYE-kleen)

Declomycin Oral Side Effects

Diarrhea, loss of appetite, nausea, vomiting, headache, dizziness, lightheadedness, or rectal discomfort may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor immediately if any of these unlikely but serious side effects occur:

  • sunburn-like skin reaction (sun sensitivity)
  • darkening of the skin and other areas of the body (e.g., lips, inside of the mouth)
  • difficult/painful swallowing
  • unusual increase in the amount of urine (except for the expected increase in urination if you are treating SIADH)
  • unusual decrease in the amount of urine or no urine
  • unusual thirst
  • weakness
  • unusual tiredness
  • brown/gray tooth discoloration


Tell your doctor immediately if any of these rare but very serious side effects occur:

  • hearing changes (e.g., ringing in the ears, decreased hearing)
  • persistent/severe headache
  • vision changes (e.g., blurred vision)
  • easy bruising/bleeding
  • new signs of infection (e.g., persistent sore throat, fever, chills)
  • stomach/abdominal pain
  • persistent nausea/vomiting
  • yellowing eyes/skin
  • dark urine


This medication may rarely cause a severe intestinal condition (pseudomembranous colitis) due to a type of resistant bacteria. This condition may occur during treatment or weeks to months after treatment has stopped. Do not use anti-diarrhea products or narcotic pain medications if you have the following symptoms because these products may make them worse. Tell your doctor immediately if you develop:

  • persistent diarrhea
  • abdominal or stomach pain/cramping
  • blood/mucus in your stool


Use of this medication for prolonged or repeated periods may result in oral thrush or a new vaginal yeast infection. Contact your doctor if you notice white patches in your mouth, a change in vaginal discharge, or other new symptoms.

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