Cymbalta

Some medical conditions require careful monitoring during treatment with Cymbalta. Be sure to tell the doctor if you have diabetes, glaucoma, high blood pressure, or a seizure disorder. Cymbalta can cause episodes of mania (abnormally high feelings of excitement and energy), so be sure the doctor is aware if you have this condition.

Using Cymbalta is not recommended if you have liver problems or severe kidney disease.

Like other antidepressants, Cymbalta can cause drowsiness and affect judgment or motor skills. Use caution when driving, operating dangerous machinery, or participating in hazardous activities until you know how the drug affects you.

Possible food and drug interactions when taking Cymbalta

Never take Cymbalta with MAO inhibitors (see "Most important fact about this drug") or the drug thioridazine (Mellaril). Consult your doctor first before taking drugs that act on the central nervous system, such as antipsychotics, narcotic painkillers, sleep inducers, or tranquilizers.

Due to the possibility of liver damage, do not take Cymbalta if you use alcohol more than occasionally.

If Cymbalta is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Cymbalta with the following:

Antibiotics known as quinolones, such as Cipro, Floxin, and Trovan
Antidepressants known as tricyclics, including Elavil, Pamelor, and Tofranil
Antidepressants that raise serotonin levels, such as Effexor, Paxil, Prozac, and Zoloft
Antipsychotic medication known as phenothiazines, including Compazine, Prolixin, Serentil, Thorazine, and Trilafon
Flecainide (Tambocor)
Fluvoxamine
Propafenone (Rythmol)
Quinidine

Special information if you are pregnant or breastfeeding

Cymbalta had negative effects during pregnancy when given to animals. There have been no adequate studies in pregnant women. Cymbalta should be used during pregnancy only if the benefits outweigh the potential risks.

Cymbalta appears in the breast milk of animals. It is unknown whether the drug appears in human breast milk. Therefore, it's recommended that you avoid breastfeeding while taking Cymbalta.

Recommended dosage

ADULTS 18 YEARS AND OLDER

Major Depression

The total daily dose ranges from 40 milligrams (taken as one 20-milligram capsule twice a day) to 60 milligrams (taken as a 60-milligram capsule once a day or as a 30-milligram capsule twice a day).

Diabetic Peripheral Neuropathy

The recommended dose is 60 milligrams taken once daily.

Overdosage

Any medication taken in excess can have serious consequences. If you suspect an overdose, seek emergency treatment immediately.