Adipex-P

Do not take this drug if you have hardening of the arteries, symptoms of heart or blood vessel disease, an overactive thyroid gland, the eye condition known as glaucoma, or high blood pressure. Also avoid this drug if you are agitated, have ever abused drugs, or have taken an MAO inhibitor, including antidepressant drugs such as phenelzine sulfate and tranylcypromine sulfate, within the last 14 days.

Special warnings about Adipex-P

This drug can cause a rare but potentially fatal condition called primary pulmonary hypertension. Call your doctor immediately if you develop such warning signs as chest pain, shortness of breath, fainting spells, or swollen ankles.

This drug may affect your ability to perform potentially hazardous activities. Therefore, you should be extremely careful if you have to drive a car or operate machinery.

You can become psychologically dependent on this drug. Consult your doctor if you rely on this drug to maintain a state of well-being.

If you stop taking this drug suddenly after you have taken high doses for a long time, you may find you are extremely fatigued or depressed, or that you have trouble sleeping.

If you continually take too much of any appetite suppressant it can cause severe skin disorders, a pronounced inability to fall or stay asleep, irritability, hyperactivity, and personality changes.

Even if your blood pressure is only mildly high, be careful taking this drug.

Possible food and drug interactions when taking Adipex-P

Remember that this drug should never be combined with the weight-loss drug fenfluramine; very dangerous side effects could result. This drug may also react badly with alcohol. Avoid alcoholic beverages while you are taking it.

If Adipex-P is taken with certain other drugs, the effects of either can be increased, decreased, or altered. It is especially important that you check with your doctor before combining this drug with the following:

• Drugs that boost serotonin levels, such as the antidepressants fluoxetine hydrochloride, paroxetine hydrochloride, and sertraline
• Drugs classified as MAO inhibitors, including the antidepressants phenelzine sulfate and tranylcypromine sulfate
• Diabetes medications such as insulin and glyburide
• High blood pressure medications such as guanethidine