Amaryl

• Symptoms of mild low blood sugar may include:
  Blurred vision, cold sweats, dizziness, fast heartbeat, fatigue, headache, hunger, light-headedness, nausea, nervousness

• Symptoms of more severe low blood sugar may include:
  Coma, disorientation, pale skin, seizures, shallow breathing

Ask your doctor what steps you should take if you experience mild hypoglycemia. If symptoms of severe low blood sugar occur, contact your doctor immediately; severe hypoglycemia is a medical emergency.

Why should Amaryl not be prescribed?

Avoid Amaryl if you have ever had an allergic reaction to it.

Do not take Amaryl to correct diabetic ketoacidosis (a life-threatening medical emergency caused by insufficient insulin and marked by excessive thirst, nausea, fatigue, and fruity breath). This condition should be treated with insulin.

Special warnings about Amaryl

It's possible that drugs such as Amaryl may lead to more heart problems than diet treatment alone, or treatment with diet and insulin. If you have a heart condition, you may want to discuss this with your doctor.

When taking Amaryl, you should check your blood and urine regularly for abnormally high sugar (glucose) levels. The effectiveness of any oral antidiabetic, including Amaryl, may decrease with time. This may occur because of either a diminished responsiveness to the medication or a worsening of the diabetes.

Even people with well-controlled diabetes may find that stress such as injury, infection, surgery, or fever triggers a loss of control. If this happens, your doctor may recommend that you add insulin to your treatment with Amaryl or that you temporarily stop taking Amaryl and use insulin instead.

Possible food and drug interactions when taking Amaryl

If Amaryl is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Amaryl with the following:

• Airway-opening drugs such as albuterol sulfate
• Aspirin and other salicylate medications
• Chloramphenicol
• Corticosteroids such as prednisone
• Diuretics such as hydrochlorothiazide and chlorothiazide
• Estrogens such as conjugated estrogens
• Heart and blood pressure medications called beta blockers, including atenolol, metoprolol tartrate, and propranolol hydrochloride
• Isoniazid
• Major tranquilizers such as thioridazine hydrochloride
• MAO inhibitors (antidepressants such as phenelzine sulfate and tranylcypromine sulfate)
• Miconazole
• Nicotinic acid
• Nonsteroidal anti-inflammatory drugs such as diclofenac sodium, ibuprofen, mefenamic acid, and naproxen
• Oral contraceptives
• Phenytoin
• Probenecid
• Sulfa drugs such as sulfamethoxazole and trimethoprim
• Thyroid medications such as levothyroxine
• Warfarin