Clinoril

Special warnings about Clinoril

Stomach ulcers and bleeding can occur without warning, especially if you are 65 or older. These and other side effects are also more likely if you have poor kidney function.

This drug should be used with caution if you have kidney or liver disease; it can cause liver inflammation in some people.

Do not take aspirin or any other anti-inflammatory medications while taking Clinoril, especially if you have asthma, unless your doctor tells you to do so.

Nonsteroidal anti-inflammatory drugs such as Clinoril can hide the signs and symptoms of an infection. Be sure your doctor knows about any infection you may have.

If you develop a skin rash, blisters, itching, or fever, it may be a reaction to Clinoril. Contact your doctor immediately for proper evaluation and treatment.

Clinoril can cause vision problems. If you experience a change in your vision, inform your doctor.

If you have heart disease or high blood pressure, this drug can increase water retention. Use with caution.

If you develop pancreatitis (inflammation of the pancreas), Clinoril should be stopped immediately and not restarted.

Clinoril may cause you to become drowsy or less alert. If this happens, driving or operating dangerous machinery or participating in any hazardous activity that requires full mental alertness is not recommended.

Possible food and drug interactions when taking Clinoril

If Clinoril is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Clinoril with the following:

• Aspirin
• Blood thinners such as warfarin sodium
• Cyclosporine
• Diflunisal
• Dimethyl sulfoxide (DMSO)
• Diuretics
• DMSO
• Lithium
• Loop diuretics such as furosemide
• Methotrexate
• Oral diabetes medications
• Other nonsteroidal anti-inflammatory drugs
• The anti-gout medication probenecid

Special information if you are pregnant or breastfeeding

The effects of Clinoril during pregnancy have not been adequately studied; drugs of this class are known to cause birth defects, such as prenatal heart problems. If you are pregnant or plan to become pregnant, inform your doctor immediately. Clinoril may appear in breast milk and could affect a nursing infant. If this medication is essential to your health, your doctor may advise you to discontinue breastfeeding until your treatment with Clinoril is finished.