Clozaril

Special warnings about Clozaril

Clozaril can cause drowsiness, especially at the start of treatment. For this reason, and also because of the potential for seizures, you should not drive, swim, climb, or operate dangerous machinery while you are taking this medication, at least in the early stages of treatment.

Even though you will have blood tests weekly for the first 6 months of treatment and every other week after that, you should stay alert for early symptoms of agranulocytosis: weakness, lethargy, fever, sore throat, a general feeling of illness, a flu-like feeling, or ulcers of the lips, mouth, or other mucous membranes. If any such symptoms develop, tell your doctor immediately.

Especially during the first 3 weeks of treatment, you may develop a fever. If you do, notify your doctor.

While taking Clozaril, do not drink alcohol or use drugs of any kind, including over-the-counter medicines, without first checking with your doctor.

If you take Clozaril, you must be monitored especially closely if you have either the eye condition called narrow-angle glaucoma or an enlarged prostate; Clozaril could make these conditions worse.

On rare occasions, Clozaril can cause intestinal problems--constipation, impaction, or blockage--that can, in extreme cases, be fatal.

In very rare cases, Clozaril has been known to cause a potentially fatal inflammation of the heart. This problem is most likely to surface during the first month of treatment, but has also occurred later. Warning signs include unexplained fatigue, shortness of breath, fever, chest pain, and a rapid or pounding heartbeat. If you develop these symptoms, see your doctor immediately. Even a suspicion of heart inflammation warrants discontinuation of Clozaril.

Especially when you begin taking Clozaril, you may be troubled by a dramatic drop in blood pressure whenever you first stand up. This can lead to light-headedness, fainting, or even total collapse and cardiac arrest. Clozaril also tends to increase your heart rate. Both problems are more dangerous for someone with a heart problem. If you suffer from one, make sure the doctor knows about it.