Clozaril

Recommended dosage for Clozaril

ADULTS

Your doctor will carefully individualize your dosage and monitor your response regularly.

The usual recommended initial dose is half of a 25-milligram tablet (12.5 milligrams) 1 or 2 times daily. Your doctor may increase the dosage in increments of 25 to 50 milligrams a day to achieve a daily dose of 300 to 450 milligrams by the end of 2 weeks. Dosage increases after that will be only once or twice a week and will be no more than 100 milligrams each time. Dosage is increased gradually because rapid increases and higher doses are more likely to cause seizures and changes in heart rhythm. The most you can take is 900 milligrams a day divided into 2 or 3 doses.

Your doctor will determine long-term dosage depending upon your response and results of the regular blood tests.

CHILDREN

Safety and efficacy have not been established for children up to 16 years of age.

Overdosage

Any medication taken in excess can have serious consequences. If you suspect an overdose, seek emergency medical attention immediately.

• Symptoms of overdose with Clozaril may include:
  Coma, delirium, drowsiness, excess salivation, low blood pressure, faintness, pneumonia, rapid heartbeat, seizures, shallow breathing or absence of breathing