Comtan

Pronounced: COM-tan
Generic name: Entacapone

Why is Comtan prescribed?

Comtan is used for Parkinson's disease. It is prescribed when doses of the combination drug levodopa/carbidopa (Sinemet) begin to wear off too soon. By extending the effect of each dose of Sinemet, it frees the patient from the stiffness and tremors of Parkinson's for a longer period of time.

Comtan works by inhibiting the effect of an enzyme that breaks down the levodopa in Sinemet. It has no effect on Parkinson's disease when used by itself.

Most important fact about Comtan

Comtan's value lies in its ability to extend Sinemet's effectiveness when it begins to decline. It is helpful only when taken with the other drug, and has no benefit when used alone.

How should you take Comtan?

Comtan should be taken with each dose of Sinemet. It can be taken up to 8 times per day, with or without food.

--If you miss a dose...

Take it along with a dose of Sinemet as soon as you remember. If it is almost time for your next dose, skip the one you missed and go back to your regular schedule. Never take 2 doses at the same time.

--Storage instructions...

Store at room temperature.

What side effects may occur?

Side effects cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking Comtan.

• More common side effects may include:
  Abdominal pain, back pain, constipation, diarrhea, discoloration of urine, dizziness, nausea, onset of new movement disorders, tired feeling, vomiting

Why should Comtan not be prescribed?

If Comtan gives you an allergic reaction, you won't be able to use it. It is prescribed only with caution for people with liver disease.

Special warnings about Comtan

Use of Comtan can cause low blood pressure, with symptoms such as dizziness, nausea, fainting, and sweating. Be careful when standing up after you have been sitting or lying down. See how the medication affects you before you drive a car or operate machinery.

Nausea and diarrhea are especially common side effects of Comtan, developing in more than 10 percent of those taking it. In rare cases, the problem is severe. Comtan may also cause hallucinations, and occasionally triggers new movement disorders. In about 10 percent of those taking it, it has the harmless side effect of turning the urine a brownish-orange color.