Depakene

• More common side effects may include:
  Abdominal cramps, amnesia, breathing difficulty, depression, diarrhea, dimmed or blurred vision, drowsiness, hair loss, indigestion, infection, involuntary eye movements, loss or increase in appetite, nausea, nervousness, ringing in the ears, sleeplessness, swelling of the arms and legs due to fluid retention, throat inflammation, tremors, vomiting

Why should Depakene not be prescribed?

You should not take this drug if you have liver disease or your liver is not functioning properly, or if you have had an allergic reaction to it.

Special warnings about Depakene

Remember that liver failure is possible when taking Depakene (see "Most important fact about this drug"). Your doctor should test your liver function at regular intervals.

Also keep in mind the threat of damage to the pancreas (see "Most important fact about this drug"). This problem can develop rapidly, so contact your doctor immediately if you experience any symptoms.

In people with a rare set of genetic abnormalities called urea cycle disorders, Depakene may adversely effect the brain. Signs of a developing problem include lack of energy, repeated attacks of vomiting, and mental changes. If you suspect a problem, see your doctor immediately. Depakene may have to be discontinued.

Depakene has also been known to cause a very rare but potentially fatal skin condition. Contact your doctor if you notice any changes in your skin.

Some side effects are more likely if you have manic episodes or suffer from migraines. Your doctor will monitor your care closely if you have one of these conditions.

Because of the potential for side effects involving blood disorders, your doctor will probably test your blood before prescribing Depakene and at regular intervals while you are taking it. Bruising, hemorrhaging, or clotting disorders usually mean the dosage should be reduced or the drug should be stopped altogether.

Depakene may cause drowsiness, especially in older adults. You should not drive a car, operate heavy machinery, or engage in hazardous activity until you know how you react to the drug.