Depo-Provera

Studies of women who have used Depo-Provera for a long time have found virtually no increased risk of cancers of the breast, ovaries, liver, or cervix (mouth of the uterus). Some studies do show a slight increased risk of breast cancer in women younger than 35 years old who have taken Depo-Provera for a short time, but the increase is about three additional cases of breast cancer per 10,000 women. At the same time, Depo-Provera helps reduce the chance of cancer of the endometrium, or lining of the uterus.

Depo-Provera may cause fluid retention, so if you have conditions that may be worsened by fluid retention, such as epilepsy, migraine headaches, asthma, heart disease, or kidney disease, make sure the doctor is aware of it.

Depo-Provera tends to alter levels of blood sugar, so diabetic women need to be carefully observed by their doctors when taking Depo-Provera.

If you develop jaundice (a yellowing of the skin and whites of the eyes caused by liver disease), you probably should not receive Depo-Provera again.

Most women gain weight while they are using Depo-Provera.

While it is an excellent birth control method, Depo-Provera does not protect you against AIDS or other sexually transmitted diseases. If you are concerned about AIDS or other STDs, be sure your partner uses a condom during intercourse (or, for absolute safety, abstain from sex).

Before you start using Depo-Provera, be sure to tell your doctor if you or anyone in your family has ever had breast cancer; if you have ever had any problems with your breasts; if your menstrual periods have ever been irregular or spotty; if you have kidney disease, high blood pressure, migraine headaches, asthma, epilepsy, or a history of depression; if you or anyone in your family has or has had diabetes; or if you are taking any prescription or over-the-counter drugs.

Possible food and drug interactions when taking Depo-Provera

If Depo-Provera is taken with aminoglutethimide (Cytadren), a drug used to treat a disorder of the adrenal glands called Cushing's syndrome, it could make the Depo-Provera less potent, which could lead to unexpected pregnancy. Check with your doctor before taking Cytadren if you are on Depo-Provera.