Desyrel

If Desyrel is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Desyrel with the following:

• Antidepressant drugs known as MAO inhibitors, including phenelzine and tranylcypromine
• Other antidepressants such as fluoxetine and desipramine
• Barbiturates such as secobarbital
• Central nervous system depressants such as meperidine and triazolam
• Chlorpromazine
• Digoxin
• Drugs for high blood pressure such as clonidine and guanabenz
• Phenytoin
• Warfarin

Special information if you are pregnant or breastfeeding

The effects of Desyrel during pregnancy have not been adequately studied. If you are pregnant or planning to become pregnant, inform your doctor immediately. This medication may appear in breast milk. If treatment with this drug is essential to your health, your doctor may advise you to discontinue breastfeeding your baby until your treatment is finished.

Recommended dosage for Desyrel

ADULTS

The usual starting dosage is a total of 150 milligrams per day, divided into 2 or more smaller doses. Your doctor may increase your dose by 50 milligrams per day every 3 or 4 days. Total dosage should not exceed 400 milligrams per day, divided into smaller doses. Once you have responded well to the drug, your doctor may gradually reduce your dose. Because this medication makes you drowsy, your doctor may tell you to take the largest dose at bedtime.

Overdosage

Any medication taken in excess can have serious consequences. An overdose of Desyrel in combination with other drugs can be fatal. If you suspect an overdose, seek medical attention immediately.

• Symptoms of a Desyrel overdose may include:
  Breathing failure, drowsiness, irregular heartbeat, prolonged, painful erection, seizures, vomiting