Estring

• Storage instructions...
  Store at room temperature.

What side effects may occur?

Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue using Estring.

• Side effects may include:
  Abdominal pain, arthritis, back pain, flu-like symptoms, headaches, insomnia, joint pain, nausea, sinus inflammation, upper respiratory tract infections, vaginal discharge, vaginal discomfort or pain, vaginal inflammation or bleeding, yeast infection

Why should Estring not be prescribed?

Do not use Estring if you have unexplained vaginal bleeding. Also avoid Estring if there is a possibility that you are pregnant.

Do not use Estring if there is any chance that you have breast cancer or any other cancer stimulated by estrogen. You will also have to avoid Estring if it causes an allergic reaction.

Special warnings about Estring

Estrogen replacement therapy increases the risk of developing cancer of the lining of the uterus. The risk increases with longer use and higher doses. Therefore, you should use Estring for as short a time and at as low a dose as is necessary to relieve your symptoms. Report any unusual vaginal bleeding to you doctor immediately.

Using estrogen may also increase the risk of breast cancer, ovarian cancer, heart attack, stroke, blood clots, and gallbladder disease.

Use estrogen with caution if you have severely low blood levels of calcium (hypocalcemia).

Tell your doctor if you've ever had liver problems, high cholesterol, high blood pressure, thyroid problems, or visions problems. Using estrogen could make these conditions worse.

Estrogens can cause water retention. If you have a condition that could be affected by this—such as heart or kidney problems—your doctor will monitor you closely

While using Estring, contact your doctor right away if you develop any of the following:

• Abdominal pain, tenderness, or swelling
• Abnormal bleeding from the vagina
• Breast lumps
• Coughing up blood
• Difficulty with speech
• Dizziness or faintness
• Pains in your chest or calves
• Severe headache or vomiting
• Sudden shortness of breath
• Vision changes
• Weakness or numbness of an arm or leg
• Yellowing of skin or whites of the eyes (could signal a liver problem)