Estratest

Why should Estratest not be prescribed?

You should avoid Estratest if you are breast feeding or have any of the following conditions:

• Breast cancer or any other type of cancer that's stimulated by estrogen (except in certain special circumstances).
• Known or suspected pregnancy.
• Unexplained vaginal bleeding.
• A clotting disorder such as phlebitis, or clotting problems during previous estrogen therapy.
• Severe liver damage.

Special warnings about Estratest

Long-term estrogen replacement therapy definitely increases the risk of endometrial cancer and may increase the risk of breast cancer as well. If you have a family history of breast cancer, or if you have breast nodules or abnormal mammograms, be sure to have frequent breast exams.

Estrogen replacement drugs have been associated with an increased risk of heart disease, such as heart attack and stroke, as well as blood clots in the brain, heart, or lungs. You are at a higher risk for heart disease if you have high blood pressure, diabetes, if you smoke cigarettes, have high cholesterol, or are overweight. If you are having surgery you will need to discontinue estrogen therapy at least 4 to 6 weeks prior to the procedure because the risk for blood clots becomes higher due to the time you may be immobilized. Because estrogen replacement poses a slight theoretical danger of clotting disorders, and testosterone has been known to cause fluid retention and heart failure in people with heart, liver, or kidney disease. Take Estratest with caution if you have any of these conditions or have ever suffered a stroke. Also let the doctor know if you have asthma, epilepsy, migraines, or bone disease.

Estrogen replacement also increases the risk of gallbladder disease. Women who take birth control pills, which have the same effect, suffer an increase in gallbladder problems after 2 years of use.

Both estrogen and testosterone can cause liver problems, including benign tumors, cancers, and hepatitis. Be sure to report any pain, tenderness, or swelling in the abdomen to your doctor immediately. If you develop signs of liver disease such as yellowing of the skin and eyes, stop taking Estratest and see your doctor at once.