Flexeril

Special warnings about Flexeril

Flexeril may cause you to become drowsy or less alert; therefore, you should not drive or operate dangerous machinery or participate in any hazardous activity that requires full mental alertness until you know how this drug affects you.

You should use Flexeril with caution if you have ever been unable to urinate or if you have ever had the eye condition called glaucoma.

Possible food and drug interactions when taking Flexeril

Serious, potentially fatal reactions may occur if you take Flexeril with an antidepressant drug known as an MAO inhibitor (such as Nardil, Parnate) or if it has been less than 2 weeks since you last took an MAO inhibitor. You should closely follow your doctor's advice regarding discontinuation of MAO inhibitors before taking Flexeril.

Avoid alcoholic beverages while taking Flexeril.

If Flexeril is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Flexeril with the following:

Barbiturates such as phenobarbital
Guanethidine and other high blood pressure drugs
Other drugs that slow the central nervous system, such as Halcion and Xanax
Tramadol (Ultram)

Special information if you are pregnant or breastfeeding

The effects of Flexeril during pregnancy have not been adequately studied. If you are pregnant or plan to become pregnant, inform your doctor immediately. It is not known if Flexeril appears in breast milk. However, cyclobenzaprine is related to tricyclic antidepressants, and some of those drugs do appear in breast milk. If this medication is essential to your health, your doctor may advise you to discontinue breastfeeding your baby until your treatment is finished.

Recommended dosage

ADULTS

The usual dose is 10 milligrams 3 times a day. You should not take more than 60 milligrams a day.

CHILDREN

Safety and effectiveness of Flexeril have not been established for children under the age of 15.

Overdosage

Any medication taken in excess can have serious consequences. If you suspect a Flexeril overdose, seek medical attention immediately.

• Symptoms of Flexeril overdose may include:
  Agitation, coma, confusion, congestive heart failure, convulsions, dilated pupils, disturbed concentration, drowsiness, hallucinations, high or low temperature, increased heartbeats, irregular heart rhythms, muscle stiffness, overactive reflexes, severe low blood pressure, stupor, vomiting

High doses also may cause any of the conditions listed in "What Side Effects May Occur?"