Fortovase

Pronounced: FORT-o-vace
Generic name: Saquinavir
Other brand name: Invirase

Why is Fortovase prescribed?

Fortovase is used in the treatment of advanced human immunodeficiency virus (HIV) infection. HIV causes the immune system to break down so that it can no longer fight off other infections. This leads to the fatal disease known as acquired immune deficiency syndrome (AIDS).

Fortovase belongs to a class of HIV drugs called protease inhibitors, which work by interfering with an important step in the virus's reproductive cycle. Fortovase is used in combination with other HIV drugs called nucleoside analogues (Retrovir or Hivid, for example). The combination produces an increase in the immune system's vital CD4 cells (white blood cells) and reduces the amount of virus in the bloodstream. Fortovase should not be used by itself.

The active ingredient in Invirase is saquinavir mesylate, and although it's similar to the active ingredient in Fortovase, the two drugs are not interchangeable (see "Most important fact about this drug"). However, the drug information provided here about Fortovase also applies to Invirase.

Most important fact about Fortovase

Fortovase will not cure an HIV infection. You will continue to face the possibility of complications, including opportunistic infections (rare infections that develop only when the immune system falters, such as certain types of pneumonia, tuberculosis, and fungal infections). Therefore, it is important that you remain under the care of a doctor and keep all your follow-up appointments.

Although they contain a similar ingredient, Fortovase and Invirase are not interchangeable. When using saquinavir as the sole protease inhibitor in a combination drug regimen, Fortovase is the recommended brand. Invirase may be used only if it is combined with ritonavir (Norvir). Any switch from Invirase to Fortovase or vice versa should be made only under the supervision of your doctor.

How should you take Fortovase?

Take this medication exactly as prescribed by your doctor. Do not share this medication with anyone and do not exceed your recommended dosage. Take Fortovase with a meal or within 2 hours afterwards. This allows the drug to be properly absorbed by your body. Your doctor will perform laboratory tests before you start therapy with Fortovase and at regular intervals during your therapy to see how you are reacting to the medication.

--If you miss a dose...