Glucovance

Why should Glucovance not be prescribed?

Glucovance is processed primarily by the kidneys, and can build up to excessive levels in the body if the kidneys aren't working properly. It should be avoided if you have kidney disease or your kidney function has been impaired by a condition such as shock, blood poisoning, or a heart attack. It should also be avoided if you need to take medicine for congestive heart failure, and you'll probably be unable to use it if you have liver disease.

If you need to have an x-ray procedure done, find out if it requires injection of a contrast agent. If so, Glucovance will have to be temporarily discontinued. (Check with your doctor for instructions; do not discontinue the drug on your own.)

If you have ever had an allergic reaction to metformin, glyburide, or diabetes medications similar to glyburide, you should not take Glucovance. It also should not be prescribed if you have acute or chronic metabolic acidosis.

Special warnings about Glucovance

Avoid excessive alcohol intake while taking Glucovance. Heavy drinking increases the danger of lactic acidosis and can also trigger an attack of low blood sugar (hypoglycemia).

Missed meals, malnutrition, general debility, liver or kidney problems, other medications, and over-exertion also increase the risk of hypoglycemia. Symptoms of a mild case include cold sweats, dizziness, shakiness, and hunger. Severe hypoglycemia can lead to seizures and coma. If you notice any of the warning signs, check with your doctor immediately.

Lactic acidosis also becomes more likely when you become dehydrated. If you experience severe vomiting, diarrhea, fever, or if your fluid intake is significantly reduced, tell your doctor.

Taking Glucovance with certain diabetes drugs, such as Avandia, can increase the risk of hypoglycemia, weight gain, and liver problems. Your doctor will periodically test your liver function to guard against any problems.

Glucovance occasionally causes a mild deficiency of vitamin B ₁₂. Your doctor will check annually and may prescribe a supplement if necessary.