Glucovance

Overview

About Glucovance

Glucovance occasionally causes a mild deficiency of vitamin B ₁₂ . Your doctor will check annually and may prescribe a supplement if necessary.

Some experts suspect that the glyburide component of Glucovance may lead to more heart problems than treatment with diet alone. In a long-term trial of a similar drug, researchers noted an increase in heart-related deaths (though the overall mortality rate remained unchanged). If you have a heart condition, you may want to discuss this potential risk with your doctor.

Possible food and drug interactions when taking Glucovance

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If Glucovance is taken with certain other drugs, the effects of either drug could be increased, decreased, or altered. It is especially important to check with your doctor before combining Glucovance with the following:

Airway-opening drugs such as Proventil and Ventolin
Beta-blockers (heart and blood-pressure drugs such as atenolol and metoprolol)
Birth control pills
Calcium channel blockers (heart medications) such as nifedipine and verapamil
Chloramphenicol
Ciprofloxacin
Estrogens
Furosemide, hydrochlorothiazide and other diuretics
Isoniazid
Major tranquilizers such as chlorpromazine
MAO inhibitors such as the antidepressants phenelzine and tranylcypromine
Nonsteroidal anti-inflammatory drugs such as ibuprofen and naproxen
Niacin
Phenytoin
Probenecid
Steroids such as prednisone
Sulfa drugs such as sulfamethoxazole
Thyroid medications such as levothyroxine
Warfarin

Special information if you are pregnant or breastfeeding

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Glucovance is not recommended during pregnancy. To control blood sugar during this crucial period, most doctors prefer insulin instead of Glucovance. If you are pregnant or plan to become pregnant, inform your doctor immediately.

You'll also need to avoid Glucovance while breastfeeding. If blood sugar becomes a problem, your doctor can prescribe insulin.