Glucovance

Overview

About Glucovance

Some experts suspect that the glyburide component of Glucovance may lead to more heart problems than treatment with diet alone. In a long-term trial of a similar drug, researchers noted an increase in heart-related deaths (though the overall mortality rate remained unchanged). If you have a heart condition, you may want to discuss this potential risk with your doctor.

Possible food and drug interactions when taking Glucovance

If Glucovance is taken with certain other drugs, the effects of either drug could be increased, decreased, or altered. It is especially important to check with your doctor before combining Glucovance with the following:

Airway-opening drugs such as Proventil and Ventolin
Beta-blockers (heart and blood-pressure drugs such as Inderal and Tenormin)
Birth control pills
Calcium channel blockers (heart medications) such as Calan, Isoptin, and Procardia
Chloramphenicol (Chloromycetin)
Ciprofloxacin (Cipro)
Estrogens such as Premarin
HydroDiuril, Lasix, and other diuretics
Isoniazid (Rifamate)
Major tranquilizers such as Compazine, Stelazine, and Thorazine
MAO inhibitors such as the antidepressants Nardil and Parnate
Nonsteroidal anti-inflammatory drugs such as Advil, Motrin, Naprosyn, and Voltaren
Niacin (Niacor, Niaspan)
Phenytoin (Dilantin)
Probenecid
Steroids such as prednisone (Deltasone)
Sulfa drugs such as Bactrim
Thyroid medications such as Synthroid
Warfarin (Coumadin)

Special information if you are pregnant or breastfeeding

Glucovance is not recommended during pregnancy. To control blood sugar during this crucial period, most doctors prefer insulin instead of Glucovance. If you are pregnant or plan to become pregnant, inform your doctor immediately.

You'll also need to avoid Glucovance while breastfeeding. If blood sugar becomes a problem, your doctor can prescribe insulin.