Glucovance

The recommended starting dose is 1.25 milligrams of glyburide with 250 milligrams of metformin once or twice daily with meals. The dosage can be increased every two weeks until blood sugar levels are controlled. The maximum recommended daily dosage of Glucovance for previously untreated patients is 10 milligrams of glyburide with 2,000 milligrams of metformin.

For patients previously treated with glyburide (or a similar drug) or metformin:

The recommended starting dose of Glucovance is either 2.5 or 5 milligrams of glyburide with 500 milligrams of metformin twice daily with meals. The maximum recommended daily dosage of Glucovance for previously treated patients is 20 milligrams of glyburide with 2,000 milligrams of metformin.

CHILDREN

Glucovance is not for use in children.

OLDER ADULTS

Since kidney function declines with age, it should be closely monitored in people taking Glucovance after age 65. Older patients are usually not prescribed the maximum recommended dose of Glucovance.

Overdosage

An overdose of Glucovance can cause an attack of hypoglycemia requiring immediate treatment. If you experience any of the symptoms listed in "Special warnings about this medication," see a doctor immediately.

An excessive dose of Glucovance can also trigger lactic acidosis. If you begin to notice the warning signs listed in "Most important fact about this drug," seek emergency treatment.