Lupron Depot

Pronounced: LU-pron DEE-poe
Generic name: Leuprolide acetate

Why is Lupron Depot prescribed?

Lupron is a synthetic version of the naturally occurring gonadotropin releasing hormone (GnRH). Lupron suppresses shedding of the endometrium (lining of the uterus) during menstruation and is used to treat endometriosis, a condition in which cells from the endometrium grow outside of the uterus. Endometriosis causes painful growths to form around the outside of the uterus, fallopian tubes, and ovaries.

Two forms of Lupron--Lupron Depot 3.75 and Lupron Depot 11.25--are prescribed to relieve the pain of endometriosis and shrink the growths. (The hormonal medication norethindrone acetate is often added to the regimen.) Three other forms of Lupron--Lupron Depot 7.5, Lupron Depot 22.5, and Lupron Depot 30--are prescribed to relieve the symptoms of advanced prostate cancer.

The first two forms of Lupron are also used before surgery, along with iron, to treat anemia caused by fibroids (tumors) in the uterus when iron alone is not effective. Some doctors also prescribe Lupron for infertility and for early puberty.

Most important fact about Lupron Depot

Lupron lowers estrogen levels, which can lead to a decrease in bone density in both men and women. Decreased bone density could increase your risk of osteoporosis, or brittle bone disease, later in life. Consequently, the drug is not usually given for longer than 6 months at a time.

How should you take Lupron Depot?

Lupron must be given under the supervision of a physician. It is given by injection once a month, every 3 months, or every 4 months, depending on the form you've been prescribed.

--If you miss a dose...

Women who miss their monthly injections of Lupron Depot 3.75 may experience resumption of menstrual bleeding.

--Storage instructions...

Lupron does not need to be refrigerated. Protect from freezing.

Lupron Depot side effects

Side effects cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking Lupron.