Macrodantin

Hemolytic anemia (destruction of red blood cells) has occurred in people taking nitrofurantoin.

Continued or prolonged use of this drug may result in growth of bacteria that do not respond to it. This can cause a renewed infection, so it is important that your doctor monitor your condition on a regular basis.

Possible food and drug interactions when taking Macrodantin

If nitrofurantoin is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining nitrofurantoin with the following:

• Magnesium trisilicate
• The gout drugs probenecid and sulfinpyrazone and other drugs that increase the amount of uric acid in the urine

Special information if you are pregnant or breastfeeding

The safety of nitrofurantoin during pregnancy and breastfeeding has not been established. Nitrofurantoin does appear in human breast milk. If you are pregnant or breastfeeding or you plan to become pregnant or breastfeed, inform your doctor immediately.

Recommended dosage for Macrodantin

Treatment with nitrofurantoin should be continued for 1 week or for at least 3 days after obtaining a urine specimen free of infection. If your infection has not cleared up, your doctor should re-evaluate your case.

ADULTS

The recommended dosage of Macrodantin is 50 to 100 milligrams taken 4 times a day. For long-term treatment, your doctor may reduce your dosage to 50 to 100 milligrams taken at bedtime.

The recommended dosage of Macrobid is one 100 milligram capsule every 12 hours for 7 days.

CHILDREN

This medication should not be prescribed for children under 1 month of age.

The recommended daily dosage of Macrodantin for infants and children over 1 month of age is 5 to 7 milligrams per 2.2 pounds of body weight, divided into 4 doses over 24 hours.

For the long-term treatment of children, the doctor may prescribe daily doses as low as 1 milligram per 2.2 pounds of body weight taken in 1 or 2 doses per day.