Metaglip

Special information if you are pregnant or breastfeeding

If you are pregnant or plan to become pregnant, tell your doctor immediately. Metaglip has not been adequately studied in pregnant women and should not be taken during pregnancy unless the potential benefit outweighs the potential risk. Since studies suggest the importance of maintaining normal blood sugar levels during pregnancy, your doctor may prescribe insulin injections instead.

It is not known whether Metaglip appears in human breast milk. Therefore, you should discuss with your doctor whether to discontinue the medication or to stop breastfeeding. If the medication is discontinued and if diet alone does not control blood sugar levels, your doctor may prescribe insulin injections.

Recommended dosage

ADULTS

Your doctor will start therapy at a low dose and increase it until your blood sugar levels are under control.

For patients not previously treated with diabetes medications

The recommended starting dose is 2.5 milligrams of glipizide with 250 milligrams of metformin once a day. If your fasting blood sugar levels are particularly high, you doctor may have you take 2.5 milligrams of glipizide with 500 milligrams of metformin twice a day.

The daily dosage can be increased by one tablet every 2 weeks until blood sugar levels are controlled. The maximum daily dose is 10 milligrams of glipizide with 2,000 milligrams of metformin.

For patients previously treated with glipizide (or a similar drug) or metformin

The recommended starting dose of Metaglip is either 2.5 or 5 milligrams of glipizide with 500 milligrams of metformin twice a day. If this regimen doesn't control your blood sugar, the daily dose can be increased by increments of up to 5 milligrams (glipizide)/500 milligrams (metformin). The maximum daily dose is 20 milligrams of glipizide with 2,000 milligrams of metformin.

For patients on combination therapy taking separate doses of glipizide and metformin

The maximum daily dose should not exceed your current doses of glipizide and metformin. The usual daily starting dose is either 2.5 or 5 milligrams of glipizide with 500 milligrams of metformin. If this regimen doesn't control your blood sugar, the daily dose can be increased by increments of up to 5 milligrams (glipizide)/500 milligrams (metformin). The maximum daily dose is 20 milligrams of glipizide with 2,000 milligrams of metformin.