Monopril

This drug should be used with caution if you are on dialysis. There have been reports of extreme allergic reactions during dialysis in people taking ACE inhibitors such as Monopril. There have also been reports of severe allergic reactions in people given bee or wasp venom to protect against stings.

Possible food and drug interactions when taking Monopril

If Monopril is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Monopril with the following:

• Antacids
• Lithium
• Potassium preparations
• Potassium-sparing diuretics such as amiloride and spironolactone
• Thiazide diuretics such as chlorothiazide

Special information if you are pregnant or breastfeeding

ACE inhibitors such as Monopril have been shown to cause injury and even death in the developing baby when used in pregnancy during the second or third trimesters. If you are pregnant your doctor should discontinue the use of this medication as soon as possible. If you plan to become pregnant and are taking Monopril, contact your doctor immediately to discuss the potential hazard to your unborn child. Monopril appears in breast milk and could affect a nursing infant. If this medication is essential to your health, your doctor may advise you to discontinue breastfeeding until your treatment with this medication is finished.

Recommended dosage for Monopril

ADULTS

High Blood Pressure

The usual initial dose is 10 milligrams, taken once a day, either alone or when added to a diuretic. Dosage, after blood pressure is adjusted, should be 20 to 40 milligrams a day in a single dose. For some patients, the doctor may divide the daily total into several smaller doses.

Diuretic use should, if possible, be stopped before using Monopril. If not, your physician may give an initial dose of 10 milligrams under his supervision before any further medication is prescribed.

Heart Failure

The usual starting dose is 10 milligrams once a day, with diuretics and possibly digitalis. Your doctor will gradually increase the dose to one that works for you—usually between 20 milligrams daily and the maximum dose of 40 milligrams per day. If your kidneys are impaired you will probably start with a dose of 5 milligrams.

CHILDREN

The safety and effectiveness of Monopril have not been established in children.

Overdosage

Any medication taken in excess can have serious consequences. If you suspect an overdose, seek medical attention immediately.

The primary effect of a Monopril overdose is likely to be a sudden drop in blood pressure.