Norpace

ADULTS

Your doctor will adjust your dosage according to your own response to, and tolerance of, Norpace or Norpace CR.

The usual dosage range of Norpace and Norpace CR is 400 milligrams to 800 milligrams per day, divided into smaller doses.

The recommended dosage for most adults is 600 milligrams per day, divided into smaller doses (either 150 milligrams every 6 hours for immediate-release Norpace or 300 milligrams every 12 hours for Norpace CR).

For those who weigh less than 110 pounds, the recommended dosage is 400 milligrams per day, divided into smaller doses (either 100 milligrams every 6 hours for immediate-release Norpace or 200 milligrams every 12 hours for Norpace CR.

For people with severe heart disease, the starting dose will be 100 milligrams of immediate-release Norpace every 6 to 8 hours. Your doctor will adjust the dosage gradually and watch you closely for any signs of low blood pressure or heart failure.

For people with moderately reduced kidney or liver function, the dosage is 400 milligrams per day, divided into smaller doses (either 100 milligrams every 6 hours for immediate-release Norpace or 200 milligrams every 12 hours for Norpace CR). This dosage is also recommended for people with glaucoma (high pressure in the eye), urinary retention, or an enlarged prostate gland, in the event they develop side effects.

For those who have severe kidney impairment, the dosage of immediate-release Norpace is 100 milligrams; the times will vary with the individual as determined by your doctor.

Norpace CR is not recommended for people with severe kidney disease.

CHILDREN

Dosage in children to age 18 is based on body weight. The total daily dosage should be divided into equal doses taken orally every 6 hours or at intervals that are best for the individual.

Overdosage

Any medication taken in excess can have serious consequences. An overdose of Norpace can be fatal. If you suspect an overdose, seek medical treatment immediately.

• The symptoms of Norpace overdose may include:
  Cessation of breathing, irregular heartbeat, loss of consciousness, low blood pressure, slow heartbeat, worsening of congestive heart failure