Norpramin

Generic name: Desipramine hydrochloride

Why is Norpramin prescribed?

Norpramin is used in the treatment of depression. It is one of a family of drugs called tricyclic antidepressants. Drugs in this class are thought to work by affecting the levels of the brain's natural chemical messengers (called neurotransmitters), and adjusting the brain's response to them.

Norpramin has also been used to treat bulimia and attention deficit disorders, and to help with cocaine withdrawal.

Most important fact about Norpramin

Serious, sometimes fatal, reactions have been known to occur when drugs such as Norpramin are taken with another type of antidepressant called an MAO inhibitor. Drugs in this category include phenelzine and tranylcypromine. Do not take Norpramin within two weeks of taking one of these drugs. Make sure your doctor and pharmacist know of all the medications you are taking.

How should you take Norpramin?

Norpramin should be taken exactly as prescribed.

Do not stop taking Norpramin if you feel no immediate effect. It can take up to 2 or 3 weeks for improvement to begin.

Norpramin can cause dry mouth. Sucking hard candy or chewing gum can help this problem.

• If you miss a dose...
  If you take several doses per day, take the forgotten dose as soon as you remember, then take any remaining doses for the day at evenly spaced intervals. If you take Norpramin once a day at bedtime and don't remember until morning, skip the missed dose. Never try to "catch up" by doubling the dose.

• Storage instructions...
  Norpramin can be stored at room temperature. Protect it from excessive heat.

What side effects may occur?

Side effects cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking Norpramin.

• Side effects may include:
  Anxiety, confusion, dizziness, dry mouth, frequent urination or problems urinating, high blood pressure, hallucinations, hives, impaired coordination, irregular heartbeat, low blood pressure, numbness, rapid heartbeat, sensitivity to sunlight, sex drive changes, tingling, tremors