Orinase

Special information if you are pregnant or breastfeeding

The effects of Orinase during pregnancy have not been adequately established in humans. Since Orinase has caused birth defects in rats, it is not recommended for use by pregnant women. Therefore, if you are pregnant or planning to become pregnant, you should take Orinase only on the advice of your physician. Since studies suggest the importance of maintaining normal blood sugar (glucose) levels during pregnancy, your physician may prescribe injected insulin during your pregnancy. While it is not known if Orinase enters breast milk, other similar medications do. Therefore, you should discuss with your doctor whether to discontinue the medication or to stop breastfeeding. If the medication is discontinued, and if diet alone does not control glucose levels, your doctor will consider giving you insulin injections.

Recommended dosage

Dosage levels are based on individual needs.

ADULTS

Usually an initial daily dose of 1 to 2 grams is recommended. Maintenance therapy usually ranges from 0.25 to 3 grams daily. Daily doses greater than 3 grams are not recommended.

CHILDREN

Safety and effectiveness have not been established in children.

OLDER ADULTS

Older, malnourished, or debilitated people, or those with impaired kidney or liver function, are usually prescribed lower initial and maintenance doses to minimize the risk of low blood sugar (hypoglycemia).

Overdosage

Any medication taken in excess can have serious consequences. An overdose of Orinase can cause low blood sugar (see "Special warnings about this medication"). Eating sugar or a sugar-based product will often correct mild hypoglycemia. If you suspect an overdose, seek medical attention immediately.