Parnate

Generic name: Tranylcypromine sulfate

Why is Parnate prescribed?

Parnate is prescribed for the treatment of major depression—that is, a depressed mood that lasts for at least 2 weeks and interferes with daily functioning. Major depression is marked by at least 4 of the following 8 symptoms: changes in appetite, changes in sleep patterns, agitation or listlessness, loss of interest in usual activities or a decrease in sex drive, fatigue, feelings of guilt or worthlessness, slowed thinking or difficulty concentrating, and thoughts of suicide.

Parnate is a member of the class of drugs known as monoamine oxidase (MAO) inhibitors. It works by increasing concentrations of the brain chemicals epinephrine, norepinephrine, and serotonin.

Most important fact about Parnate

Parnate is a potent drug with the capability of producing serious side effects. It is typically prescribed only if other antidepressants fail, and then only for adults who are under close medical supervision. It is considered especially risky because it can interact with a long list of drugs and foods to produce life-threatening side effects (see "Possible food and drug interactions when taking this medication").

How should you take Parnate?

Your doctor will adjust the dosage of Parnate according to your individual needs and response. The drug usually produces improvement within 48 hours to 3 weeks after starting therapy.

• If you miss a dose...
  Take it as soon as you remember. If it is within 2 hours of your next dose, skip the one you missed and go back to your regular schedule. Never take 2 doses at once.

• Storage instructions...
  Store at room temperature.

What side effects may occur?

Side effects cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking Parnate.

• Side effects may include:
  Blood disorders, diarrhea, dizziness, drowsiness, dry mouth, insomnia, muscle spasm, nausea, overstimulation, rapid or irregular heartbeat, restlessness, ringing in the ears, water retention, weakness, weight loss