Plavix

Special warnings about Plavix

If you've ever had a stomach ulcer or bleeding in the digestive tract, make sure the doctor is aware of it; Plavix should be used with caution. The drug should also be used carefully if you suffer from problems inside the eyes, have bleeding problems due to severe liver disease, or expect to be at risk of bleeding from any other cause.

Plavix may cause serious skin reactions such as toxic epidermal necrolysis, which is characterized by a large portion of skin turning red and peeling off (like a burn); it may also cause blisters. Contact your doctor immediately if these symptoms develop.

In extremely rare cases (about 4 in a million), a dangerous bleeding problem called thrombotic thrombocytopenic purpura has been known to develop in patients taking Plavix. Signs include fever and bleeding under the skin. Call your doctor immediately if you develop these symptoms.

Possible food and drug interactions when taking Plavix

Plavix increases the clot-fighting effect of aspirin. The two drugs are often taken together, and combined treatment has lasted for up to one year.

If Plavix is taken with certain other drugs, the effects of either could be increased, decreased, or altered. Ask your doctor before starting any new drug; and be doubly careful before combining Plavix with the following:

• Aspirin
• Fluvastatin
• Nonsteroidal anti-inflammatory drugs
• Phenytoin
• Tamoxifen
• Tolbutamide
• Torsemide
• Warfarin

Special information if you are pregnant or breastfeeding

The effects of Plavix during pregnancy have not been adequately studied. If you are pregnant or plan to become pregnant, inform your doctor immediately. Use Plavix during pregnancy only if absolutely necessary. Do not breastfeed while taking Plavix, since the drug may appear in breast milk.

Recommended dosage for Plavix

ADULTS

The usual dose is 75 milligrams once a day. To give people with unstable angina an extra boost, their first dose is usually increased to 300 milligrams.

CHILDREN

The safety and effectiveness of Plavix have not been established in children.

Overdosage

Any medication taken in excess can have serious consequences. If you suspect an overdose of Plavix, seek medical attention immediately.

• Potential symptoms of Plavix overdose may include:
  Difficulty breathing, exhaustion, prolonged bleeding, stomach or intestinal bleeding, vomiting